Anti-EIF2C2 (AGO2) (Human) mAb (Monoclonal Antibody)
Monoclonal Antibody of 200 µl targeting EIF2C2/AGO2 for IP, RIP, WB.
| Target | EIF2C2/AGO2 |
|---|---|
| Product Type | Antibody |
| Application | IP, RIP, WB |
| Clonality | Monoclonal |
| Conjugate | Unlabeled |
| Isotype | IgG2a λ |
| Immunogen | (180 amino acids. About terminal region of N) EIF2C2 partial-length recombinant |
| Host Species | Mouse |
| Species Reactivity | Human |
| Formulation | 200 μg IgG in 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained. |
| Research Area | Epigenetics |
| Description/Background | Eukaryotic translation initiation factor 2C, subunit 2 (EIF2C2; AGO2), is a member of the argonaute protein family. It is a core component of RNA-induced silencing complex (RISC). The EIF2C2 belonging to the human argonaute protein family possesses endonuclease activity and functions as a slicer in gene silencing pathways. It recognizes and cleaves target mRNA by RNA interference. In small interference RNA (siRNA) pathway, EIF2C2 forms a complex with EIF2C1 and siRNA, and in microRNA (miRNA) pathway, it binds EIF2C3 to miRNA. EIF2C2 expression is controlled by epidermal growth factor receptor and mitogen-activated protein kinase signaling in human breast cancer cell line. |
| Storage Temperature | -20°C |
| Protocols | IP, RIP, WB |
| Clone Number | 1B1-E2H5 |
| Concentration | 1 mg/mL |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
