| Target | CD63 (LAMP-3) |
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| Product Type | Antibody |
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| Application | FCM, ELISA, WB |
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| Clonality | Monoclonal |
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| Conjugate | Biotin |
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| Isotype | IgG2b ĸ |
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| Immunogen | Human prostate carcinoma cell line (PC3) derived exosomes (prepared by ultracentrifugation from cultured supernatant) |
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| Host Species | Mouse |
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| Species Reactivity | Human |
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| Formulation | PBS containing 1% BSA and 0.1% ProClin 950 |
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| Research Area | Cancer, Immunology, Cell surface antigens, Epigenetics, Exosomes, RNA-RNP Network |
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| Description/Background | CD63 antigen, also known as LAMP-3, is a tetraspanin characterized by four transmembrane domains and a member of the transmembrane 4 superfamily. CD63 is the first characterized tetraspanin. CD63 has broad tissue distribution and may play multiple roles in a variety of cellular processes such as immune response and tumorigenesis, but its function has not been elucidated entirely. It is reported that CD63 is abundant in tetraspanin-enriched microdomains (TEMs) and a certain type of cellular compartment, such as late endosomes and lysosomes, while the tetraspanin-rich small lipid bilayers are secreted into extracellular fluid as a certain type of extracellular vesicles, called exosome. Because of various exosome features, CD63, one of the representative exosome surface proteins, is thought to be related to intercellular communication. |
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| Storage Temperature | This antibody solution is stable for one year from the date of purchase when stored at 4°C. |
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| Protocols | FCM, ELISA, WB |
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| Clone Number | C047-1 |
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| Concentration | 1 mg/mL |
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| Source | Purified IgG from hybridoma supernatant |
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| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |
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