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Anti-Sap155 mAb (Monoclonal Antibody)

D221-3
Antibody
100 μg

$343.87

DATA SHEET

SF3 is a U2 snRNP-associated protein complex essential for spliceosome assembly and splicing catalysis of the major spliceosome. SF3 contains the Spliceosome-Associated Proteins, Sap 49, 130, 145, and 155. Sap155/Sf3b1 is an essential subunit of the U2 snRNP for mRNA splicing and has also been identified in the minor (U12-dependent) spliceosome. Sap155 interacts with the mammalian PcG (Polycomb group) proteins, Mel18 and Ring1B by the yeast two-hybrid system. Sap155 contains numerous Cdk consensus phosphorylation sites in its N-terminus and is phosphorylated prior to catalytic step II of the splicing pathway. Sap155 serves as a substrate for cyclin E-cdk2 in vitro, suggesting that pre-mRNA splicing may be linked to the cell cycle machinery in mammalian cells.

This monoclonal antibody reacts with Sap155 (155 kDa) on Western blotting, Immunoprecipitation and Immunocytochemistry.

TargetSap155
Product TypeAntibody
ApplicationICC, IP, WB
ClonalityMonoclonal
ConjugateUnlabeled
IsotypeIgG2b
ImmunogenRecombinant Sap155 (98-198 a.a.)
Host SpeciesMouse
Species ReactivityHuman, Mouse
Formulation100 μg IgG in 100 μl PBS containing 50% glycerol, pH 7.2. Contains nopreservatives.
Research AreaCancer, Epigenetics
Storage Temperature-20°C
ProtocolsICC, IP, WB
Clone Number16
Concentration1 mg/mL
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
D221-3
Antibody
100 μg

$343.87

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