RNF34 Rabbit pAb
| Target | RNF34 |
|---|---|
| Product Type | Antibody |
| Application | ICC, IF, WB |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human RNF34 (NP_079402.2). |
| Host Species | Rabbit |
| Species Reactivity | Human |
| Formulation | PBS with 0.02% sodium azide,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | The protein encoded by this gene contains a RINF finger, a motif known to be involved in protein-Protein A Affinity purificationnd protein-DNA interactions. This protein interacts with DNAJA3/hTid-1, which is a DnaJ protein reported to function as a modulator of apoptosis. Overexpression of this gene in Hela cells was shown to confer the resistance to TNF-alpha induced apoptosis, suggesting an anti-apoptotic function of this protein. This protein can be cleaved by caspase-3 during the induction of apoptosis. This Protein A Affinity purificationlso targets p53 and phospho-p53 for degradation. Alternatively splicing results in multiple transcript variants encoding distinct isoforms. |
| Protocols | ICC, IF, WB |
| Molecular Weight | 42kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |