PFKFB3 Rabbit mAb
Target | PFKFB3 |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human PFKFB3 (NP_004557.1). |
Host Species | Rabbit |
Species Reactivity | Human, Mouse |
Formulation | PBS with 0.05% proclin300,0.05% BSA,50% glycerol |
Research Area | Cancer, Immunology, Metabolism |
Description/Background | The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and prevention of apoptosis. It functions as a regulator of cyclin-dependent kinase 1, linking glucose metabolism to cell proliferation and survival in tumor cells. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
Protocols | WB |
Molecular Weight | 60kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |