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mTOR Rabbit pAb

CNA2445S
Antibody
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetMTOR
Product TypeAntibody
ApplicationICC, IF, IP, WB
ClonalityPolyclonal
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human mTOR (NP_004949.1).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.02% sodium azide,50% glycerol
Research AreaCancer, Immunology, Metabolism
Description/Background

The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This kinase is a component of two distinct complexes, mTORC1, which controls protein synthesis, cell growth and proliferation, and mTORC2, which is a regulator of the actin cytoskeleton, and promotes cell survival and cell cycle progression. This Protein A Affinity purificationcts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. Inhibitors of mTOR are used in organ transplants as immunosuppressants, and are being evaluated for their therapeutic potential in SARS-CoV-2 infections. Mutations in this gene are associated with Smith-Kingsmore syndrome and somatic focal cortical dysplasia type II. The ANGPTL7 gene is located in an intron of this gene.

ProtocolsICC, IF, IP, WB
Molecular Weight289kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA2445S
Antibody
100 µl

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