Please Note: MBL International will be shutting down its operations effective December 31, 2024. Distribution of MBL products in the United States will be transferred to Cosmo Bio US on January 1st while European Distributors will remain unchanged. For any US inquiries regarding orders or support during this transition, reach out to Cosmo Bio: https://www.cosmobiousa.com/. For Non-US inquiries reach out to MBL in Japan: https://www.mblbio.com/.

Select Page

CTCF Rabbit mAb

CNA19588S
Antibody
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetCTCF
Product TypeAntibody
ApplicationChIP, ChIP-seq, CUT and Tag, ICC, IF, IP, WB
ClonalityMonoclonal
IsotypeIgG
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 628-727 of human CTCF (P49711).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.02% sodium azide,0.05% BSA,50% glycerol
Research AreaCancer, Immunology, Epigenetics
Description/Background

This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms’ tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

ProtocolsChIP, ChIP-seq, CUT and Tag, ICC, IF, IP, WB
Molecular Weight83kDa
PurityAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA19588S
Antibody
100 µl

SIGN UP