TNNC1 Rabbit pAb
| Target | TNNC1 |
|---|---|
| Product Type | Antibody |
| Application | ICC, IF, WB |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-160 of human TNNC1 (NP_003271.1). |
| Host Species | Rabbit |
| Species Reactivity | Mouse, Rat |
| Formulation | PBS with 0.02% sodium azide,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. |
| Protocols | ICC, IF, WB |
| Molecular Weight | 18kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |