CD44 Rabbit mAb
Target | CD44 |
---|---|
Product Type | Antibody |
Application | FCM, ICC, IF, IHC (P), WB |
Clonality | Monoclonal |
Isotype | IgG |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 20-178 of human CD44 (NP_000601.3). |
Host Species | Rabbit |
Species Reactivity | Human |
Formulation | PBS with 0.05% proclin300,0.05% BSA,50% glycerol |
Research Area | Cancer, Immunology |
Description/Background | The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. |
Protocols | FCM, ICC, IF, IHC (P), WB |
Molecular Weight | 82kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |