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DNA polymerase eta Rabbit pAb

CNA18331P
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetPOLH
Product TypeAntibody
ApplicationIF/ICC, WB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 322-520 of human DNA polymerase eta (NP_006493.1).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.05% Proclin300,50% glycerol
Research AreaCancer, Epigenetics
Description/BackgroundThis gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
Storage TemperatureStore at -20℃
ProtocolsIF/ICC, WB
Molecular Weight78kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA18331P
100 µl

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