K11-linkage Specific Polyubiquitin Rabbit pAb
| Target | UBB |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | A synthetic peptide corresponding to a sequence containing polyubiquitinated protein (K11 linkage). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse, Other (Wide Range), Rat |
| Formulation | PBS with 0.01% thimerosal,50% glycerol |
| Research Area | Cancer, Immunology |
| Description/Background | Polyubiquitination is a posttranslational modification where ubiquitin chains containing isopeptide bonds linking one of seven ubiquitin lysines with the C terminus of an adjoining ubiquitin are covalently attached to proteins. A crystal structure of K11-linked diubiquitin demonstrates a distinct conformation from K48- or K63-linked diubiquitin. It is important that K11-linked ubiquitin chains as critical regulators of mitotic protein degradation. |
| Protocols | WB |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |