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IRE1 Rabbit pAb

CNA17940P
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetERN1
Product TypeAntibody
ApplicationIF/ICC, IHC (P), WB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 320-410 of human IRE1 (NP_001424.3).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.05% Proclin300,50% glycerol
Research AreaCancer
Description/BackgroundThis gene encodes the transmembrane protein kinase inositol-requiring enzyme 1. The encoded protein contains two functional catalytic domains, a serine/threonine-protein kinase domain and an endoribonuclease domain. This protein functions as a sensor of unfolded proteins in the endoplasmic reticulum (ER) and triggers an intracellular signaling pathway termed the unfolded protein response (UPR). The UPR is an ER stress response that is conserved from yeast to mammals and activates genes involved in degrading misfolded proteins, regulating protein synthesis and activating molecular chaperones. This protein specifically mediates the splicing and activation of the stress response transcription factor X-box binding protein 1.
Storage TemperatureStore at -20℃
ProtocolsIF/ICC, IHC (P), WB
Molecular Weight110kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA17940P
100 µl

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