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AXIN2 Rabbit pAb

CNA17021P
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetAXIN2
Product TypeAntibody
ApplicationWB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 400-500 of human AXIN2 (NP_004646.3).
Host SpeciesRabbit
Species ReactivityMouse, Rat
FormulationPBS with 0.05% Proclin300,50% glycerol
Research AreaCancer, Epigenetics
Description/BackgroundThe Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair.
Storage TemperatureStore at -20℃
ProtocolsWB
Molecular Weight94kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA17021P
100 µl

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