AXIN2 Rabbit pAb
Target | AXIN2 |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Polyclonal |
Conjugate | unconjugated |
Isotype | IgG |
Immunogen | A synthetic peptide corresponding to a sequence within amino acids 400-500 of human AXIN2 (NP_004646.3). |
Host Species | Rabbit |
Species Reactivity | Mouse, Rat |
Formulation | PBS with 0.05% Proclin300,50% glycerol |
Research Area | Cancer, Epigenetics |
Description/Background | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. |
Storage Temperature | Store at -20℃ |
Protocols | WB |
Molecular Weight | 94kDa |
Purification | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |