CSK Rabbit pAb
Target | CSK |
---|---|
Product Type | Antibody |
Application | IF/ICC, IHC (P), WB |
Clonality | Polyclonal |
Conjugate | unconjugated |
Isotype | IgG |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 188-450 of human CSK (NP_004374.1). |
Host Species | Rabbit |
Species Reactivity | Human, Mouse, Rat |
Formulation | PBS with 0.09% Sodium azide,50% glycerol |
Research Area | Cancer |
Description/Background | The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This Protein A Affinity purificationlso phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. |
Storage Temperature | Store at -20℃ |
Protocols | IF/ICC, IHC (P), WB |
Molecular Weight | 51kDa |
Purification | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |