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CSK Rabbit pAb

CNA16824S1
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetCSK
Product TypeAntibody
ApplicationIF/ICC, IHC (P), WB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 188-450 of human CSK (NP_004374.1).
Host SpeciesRabbit
Species ReactivityHuman, Mouse, Rat
FormulationPBS with 0.09% Sodium azide,50% glycerol
Research AreaCancer
Description/BackgroundThe protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This Protein A Affinity purificationlso phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants.
Storage TemperatureStore at -20℃
ProtocolsIF/ICC, IHC (P), WB
Molecular Weight51kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA16824S1
100 µl

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