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Caspase-1 Rabbit pAb

CNA16792S1
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetCASP1
Product TypeAntibody
ApplicationWB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenRecombinant fusion protein containing a sequence corresponding to amino acids 120-297 of human Caspase-1 (NP_150634.1).
Host SpeciesRabbit
Species ReactivityHuman
FormulationPBS with 0.09% Sodium azide,50% glycerol
Research AreaCancer, Metabolism
Description/BackgroundThis gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme. This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms.
Storage TemperatureStore at -20℃
ProtocolsWB
Molecular Weight45kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA16792S1
100 µl

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