CRK/CRKII Rabbit pAb
| Target | CRK |
|---|---|
| Product Type | Antibody |
| Application | WB |
| Clonality | Polyclonal |
| Isotype | IgG |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1-304 of human CRK/CRKII (NP_058431.2). |
| Host Species | Rabbit |
| Species Reactivity | Human, Mouse |
| Formulation | PBS with 0.02% sodium azide,50% glycerol |
| Research Area | Cancer, Immunology, Metabolism |
| Description/Background | This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. |
| Protocols | WB |
| Molecular Weight | 34kDa |
| Purity | Affinity purification |
| Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |