PTPRA Rabbit pAb
Target | PTPRA |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Polyclonal |
Conjugate | unconjugated |
Isotype | IgG |
Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 175-295 of human PTPRA (NP_543030.1). |
Host Species | Rabbit |
Species Reactivity | Mouse, Rat |
Formulation | PBS with 0.01% thimerosal,50% glycerol |
Research Area | Cancer, Immunology |
Description/Background | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. |
Protocols | WB |
Molecular Weight | 91kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |