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STAT5A Rabbit pAb

CNA11779S1
100 µl

THIS ITEM HAS BEEN DISCONTINUED

DATA SHEET

TargetSTAT5A
Product TypeAntibody
ApplicationWB
ClonalityPolyclonal
Conjugateunconjugated
IsotypeIgG
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 700-800 of human STAT5A (NP_003143.2).
Host SpeciesRabbit
Species ReactivityHuman, Mouse
FormulationPBS with 0.09% Sodium azide,50% glycerol
Research AreaCancer, Epigenetics
Description/BackgroundThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene.
Storage TemperatureStore at -20℃
ProtocolsWB
Molecular Weight91kDa
PurificationAffinity purification
Regulatory StatementFor Research Use Only. Not for use in diagnostic procedures.
CNA11779S1
100 µl

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