Bcl-W Rabbit pAb
Target | BCL2L2 |
---|---|
Product Type | Antibody |
Application | WB |
Clonality | Polyclonal |
Conjugate | unconjugated |
Isotype | IgG |
Immunogen | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Bcl-W (NP_004041.2). |
Host Species | Rabbit |
Species Reactivity | Mouse, Rat |
Formulation | PBS with 0.05% proclin300,50% glycerol |
Research Area | Cancer, Immunology |
Description/Background | This gene encodes a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators. Expression of this gene in cells has been shown to contribute to reduced cell apoptosis under cytotoxic conditions. Studies of the related gene in mice indicated a role in the survival of NGF- and BDNF-dependent neurons. Mutation and knockout studies of the mouse gene demonstrated an essential role in adult spermatogenesis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring downstream PABPN1 (poly(A) binding protein, nuclear 1) gene. |
Protocols | WB |
Molecular Weight | 21kDa |
Purity | Affinity purification |
Regulatory Statement | For Research Use Only. Not for use in diagnostic procedures. |