Anti-YBX1 pAb

Polyclonal Antibody of 200 µl targeting YBX1 for IP, RIP, WB, Chip.

Target: YBX1

Product Type: Antibody

Application: ChIP, IP, RIP, WB

Clonality: Polyclonal

Conjugate: Unlabeled

Isotype: Affinity Purified Ig

Immunogen: KLH-conjugated synthetic peptide QNYQNSESGEKNEGSES （160-176 aa)

Host Species: Rabbit

Species Reactivity: Human, Hamster, Mouse, Rat

Formulation: 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Research Area: Epigenetics, RNA-RNP Network

Description/Background: The Y-box-binding protein (YBX1), family of cold shock proteins, is multifunctional and appears to regulate gene expression at both the transcriptional and posttranscriptional levels. Transcriptional targets for YBX1 includes genes associated with cell death, cell death associated receptor and tumor suppressor genes. YBX1 also up regulates genes associated with cell proliferation. YBX1 is also implicated to have an important role in inducing drug resistance on tumor cells. YBX1 binds RNAs sequence specific manner and interacts with splicing factors and plays important role in mRNA splicing and translation. Recent study suggested that competition between YBX1 and eIF4G for mRNA binding is required for efficient stimulation of eIF4F activity by PABP.

Storage Temperature: This antibody solution is stable for one year from the date of purchase when stored at -20°C.

Protocols: ChIP, IP, RIP, WB

Source: This antibody was purified from rabbit serum by affinity column chromatography. The rabbit was immunized with KLH conjugated synthetic peptide, QNYQNSESGEKNEGSES corresponding to 160-176 aa.

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.