Anti-EIF4G2 (Human/Mouse) pAb (Polyclonal Antibody)

Polyclonal Antibody of 200 µl targeting EIF4G2 for IP, RIP, WB.

Target: EIF4G2

Product Type: Antibody

Application: IP, RIP, WB

Clonality: Polyclonal

Conjugate: Unlabeled

Immunogen: Peptide bond synthesis EVNPPSDETDSSSAPSKE KLH (783-800 aa)

Host Species: Rabbit

Species Reactivity: Human, Hamster, Mouse, Rat

Formulation: 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Research Area: Epigenetics

Description/Background: The eukaryote polypeptide chain initiation factor eIF4G forms complex with the mRNA cap-binding protein eIF4E and the ATP dependent RNA helicase eIF4A, constituting the initiation factor eIF4F complex. The eIF4G plays an important role in the mechanism of translation by tethering between other components of the ribosomal initiation factors. Two forms of eIF4G have been reported as two different gene products, eIF4G1 and 2. The eIF4G2 was identified as a functional homologue of eIF4G1. The homology of eIF4G2 to eIF4G1 is particularly high in central and carboxyl portions which corresponds to the eIF4A and eIF3 binding region. The proteolysis of both eIF4G1 and eIF4G2 is associated with a decrease in cell viability and the inhibition of protein synthesis.

Storage Temperature: -20°C

Protocols: IP, RIP, WB

Concentration: 1 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.