Anti-EIF2C2 (AGO2) (Human) mAb (Monoclonal Antibody)

Monoclonal Antibody of 200 µl targeting EIF2C2/AGO2 for IP, RIP, WB.

Target: EIF2C2/AGO2

Product Type: Antibody

Application: IP, RIP, WB

Clonality: Monoclonal

Conjugate: Unlabeled

Isotype: IgG2a λ

Immunogen: (180 amino acids. About terminal region of N) EIF2C2 partial-length recombinant

Host Species: Mouse

Species Reactivity: Human

Formulation: 200 μg IgG in 200 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative iscontained.

Research Area: Epigenetics

Description/Background: Eukaryotic translation initiation factor 2C, subunit 2 (EIF2C2; AGO2), is a member of the argonaute protein family. It is a core component of RNA-induced silencing complex (RISC). The EIF2C2 belonging to the human argonaute protein family possesses endonuclease activity and functions as a slicer in gene silencing pathways. It recognizes and cleaves target mRNA by RNA interference. In small interference RNA (siRNA) pathway, EIF2C2 forms a complex with EIF2C1 and siRNA, and in microRNA (miRNA) pathway, it binds EIF2C3 to miRNA. EIF2C2 expression is controlled by epidermal growth factor receptor and mitogen-activated protein kinase signaling in human breast cancer cell line.

Storage Temperature: -20°C

Protocols: IP, RIP, WB

Clone Number: 1B1-E2H5

Concentration: 1 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.