Anti-CD63 (LAMP-3) mAb-Biotin

Target: CD63 (LAMP-3)

Product Type: Antibody

Application: FCM, ELISA, WB

Clonality: Monoclonal

Conjugate: Biotin

Isotype: IgG2b ĸ

Immunogen: Human prostate carcinoma cell line (PC3) derived exosomes (prepared by ultracentrifugation from cultured supernatant)

Host Species: Mouse

Species Reactivity: Human

Formulation: PBS containing 1% BSA and 0.1% ProClin 950

Research Area: Cancer, Immunology, Cell surface antigens, Epigenetics, Exosomes, RNA-RNP Network

Description/Background: CD63 antigen, also known as LAMP-3, is a tetraspanin characterized by four transmembrane domains and a member of the transmembrane 4 superfamily. CD63 is the first characterized tetraspanin. CD63 has broad tissue distribution and may play multiple roles in a variety of cellular processes such as immune response and tumorigenesis, but its function has not been elucidated entirely. It is reported that CD63 is abundant in tetraspanin-enriched microdomains (TEMs) and a certain type of cellular compartment, such as late endosomes and lysosomes, while the tetraspanin-rich small lipid bilayers are secreted into extracellular fluid as a certain type of extracellular vesicles, called exosome. Because of various exosome features, CD63, one of the representative exosome surface proteins, is thought to be related to intercellular communication.

Storage Temperature: This antibody solution is stable for one year from the date of purchase when stored at 4°C.

Protocols: FCM, ELISA, WB

Clone Number: C047-1

Concentration: 1 mg/mL

Source: Purified IgG from hybridoma supernatant

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.