Anti-Fas (CD95) (Human) mAb (Monoclonal Antibody)

Monoclonal Antibody targeting Fas for FCM, NT, WB.

Target: Fas

Product Type: Antibody

Application: FCM, WB

Clonality: Monoclonal

Conjugate: Unlabeled

Isotype: IgG1

Immunogen: Recombinant human Fas

Host Species: Mouse

Species Reactivity: Human

Formulation: 100 g IgG in 100 L volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Research Area: Apoptosis

Description/Background:

It is now widely accepted that apoptosis plays an important role in the selection of immature thymocytes and Ag-primed peripheral T cells. Fas (also known as CD95/APO-1) is a cell surface protein belonging to the tumor necrosis factor receptor superfamily, which is expressed in a variety of normal and neoplastic cells. Binding of FasL to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies results in rapid induction of apoptosis in Fas expressing cells. Clone ZB4 is known as Fas blocking, Fas neutralizing or Fas antagonistic antibody, whereas anti-Fas antibody (clone CH-11) is known as the agonistic antibody.

Storage Temperature: -20°C

Protocols: FCM, WB

Clone Number: ZB4

Concentration: 1 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.