Anti-Txnip (VDUP1) (Human) mAb (Monoclonal Antibody)

Thioredoxin (TRX)-binding protein (Txnip), also called Vitamin D3 up-regulated protein 1 (VDUP1) is an endogenous inhibitor of TRX.

Monoclonal Antibody of 100 μg targeting VDUP-1/Txnip for IHC, IPP, WB.

Target: VDUP-1/Txnip

Product Type: Antibody

Application: IHC, IP, WB

Clonality: Monoclonal

Conjugate: Unlabeled

Isotype: IgG1

Immunogen: Recombinant human Txnip/VDUP1

Host Species: Mouse

Species Reactivity: Human, Mouse, Rat

Formulation: 100 μg IgG in 100 μl volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Research Area: Apoptosis

Description/Background: Thioredoxin (TRX)-binding protein (Txnip), also called Vitamin D3 up-regulated protein 1 (VDUP1) is an endogenous inhibitor of TRX. Redox-dependent regulation of Txnip by mitogenic factors through Reactive oxygen species (ROS) and the specific binding of Txnip to the redox-sensitive cysteine-sulfide center of TRX modulate intracellular levels of ROS and the mitogenic activity of TRX. It has been reported that Txnip plays important roles in diverse cellular processes, including the regulation of cellular redox balance, apoptosis, proliferation, and differentiation.

Storage Temperature: -20°C

Protocols: IHC, IP, WB

Clone Number: JY2

Concentration: 1 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.