Anti-CD52 (CAMPATH-1) (Mouse) mAb (Monoclonal Antibody)

Monoclonal antibody targeting CAMPATH-1/CD52 for FCM, IPP.

Target: CAMPATH-1/CD52

Product Type: Antibody

Application: FCM, IP

Clonality: Monoclonal

Conjugate: Unlabeled

Isotype: IgG2a

Immunogen: Transgenic mouse spleen cell IL-2R alpha

Host Species: Rat

Species Reactivity: Mouse

Formulation: 100 µg IgG in 100 µL volume of PBS containing 50% glycerol, pH 7.2. No preservative is contained.

Research Area: Apoptosis

Description/Background:

CAMPATH-1, also known as CD52, is a heavily glycosylated, GPI-anchored protein expressed at high levels on almost all thymocytes, lymphocytes, monocytes, and macrophages. The function of CD52 is
unknown. However, CD52 is an exceptionally good target for complement-mediated cell lysis and
antibody-mediated cellular cytotoxicity. Humanized CAMPATH-1 antibodies have been used therapeutically to effectively deplete lymphocytes in allogeneic bone marrow transplants, hematologic malignancies, and autoimmune diseases. Clinical trials suggest CAMPATH-1 antibodies are especially promising in the treatment of leukemia, non-Hodgkin lymphomas, and rheumatoid arthritis. The apparent size of CAMPATH-1 by SDS-PAGE is 25-29 kDa; however, the actual molecule is much smaller, ~ 8-9 kDa as confirmed by total structure analysis and mass spectrometry.

Storage Temperature: -20°C

Protocols: FCM, IP

Clone Number: BTG-2G

Concentration: 1 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.