CircuLex Glucose-AGE-BSA

CircuLex Glucose-AGE-BSA of 200 µg.

Target: Glucose-AGE-BSA

Product Type: Recombinant Protein

Application: ELISA

Formulation: The glucose-AGE-BSA is supplied frozen in a buffer containing 10 mMPBS (pH 7.2).

Research Area: Cell Biology

Description/Background:

Reducing sugars react with protein amino groups to form a diverse group of protein-bound moieties with fluorescent and cross-linking properties. These compounds, called advanced glycosylation end products (AGEs), have been implicated in the structural and functional
alterations of proteins that occur during aging and long-term diabetes. Although several AGE structures have been reported (1, 2), Nε-(Carboxymethyl)lysine (CML) and Nε-(carboxyethyl)lysine (CEL) are two major stable, nonenzymatic chemical modifications of protein lysine residues resulting from glycation and oxidation reactions. However it has been proposed that AGE are not only created from glucose per se, but also from dicarbonyl compounds derived from glycation, sugar autoxidation, and sugar metabolism. It was demonstrated that various types of AGE, non-enzymatically glycated protein derivatives formed at an accelerated rate in diabetes (3), not only inhibit DNA synthesis but also induce
apoptotic cell death in human mesangial cells (4).

Storage Temperature: -20°C

Protocols: ELISA

Concentration: 1.0 mg/mL

Regulatory Statement: For Research Use Only. Not for use in diagnostic procedures.